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Fungal microsomes in a biotransformation perspective: protein nature of membrane-associated reactions
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SYSNO ASEP 0422882 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Fungal microsomes in a biotransformation perspective: protein nature of membrane-associated reactions Author(s) Svobodová, Kateřina (MBU-M) RID
Mikesková, Hana (MBU-M) RID
Petráčková, Denisa (MBU-M) RID, ORCIDSource Title Applied Microbiology and Biotechnology. - : Springer - ISSN 0175-7598
Roč. 97, č. 24 (2013), s. 10263-10273Number of pages 11 s. Language eng - English Country DE - Germany Keywords Fungal microsomes ; Cytochrome P450 ; Biodegradation Subject RIV EE - Microbiology, Virology R&D Projects TE01020218 GA TA ČR - Technology Agency of the Czech Republic (TA ČR) Institutional support MBU-M - RVO:61388971 UT WOS 000327495000003 DOI 10.1007/s00253-013-5347-2 Annotation Microsomal fraction of fungal cells grabs the attention of many researchers for it contains enzymes that play a role in biotechnologically relevant processes. Microsomal enzymes, namely, CYP450s, were shown to metabolize a wide range of xenobiotic compounds, including PAHs, PCBs, dioxins, and endocrine disruptors, and take part in other fungal biotransformation reactions. However, little is known about the nature and regulation of these membrane-associated reactions. Advanced proteomic and post-genomic techniques make it possible to identify larger numbers of microsomal proteins and thus add to a deeper study of fungal intracellular processes. In this work, proteins that were identified through a shotgun proteomic approach in fungal microsomes under various culture conditions are reviewed. However, further research is still needed to fully understand the role of microsomes in fungal biodegradation and biotransformation reactions Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2014
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