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Electrochemical sensing of 2D condensation in amyloid peptides

SYSNO ASEP	0422785
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Electrochemical sensing of 2D condensation in amyloid peptides
Author(s)	Kurzatkowska, K. (PL) Ostatná, Veronika (BFU-R)_{RID, ORCID} Hamley, I.W. (GB) Doneux, T. (BE) Paleček, Emil (BFU-R)_{RID, ORCID}
Number of authors	5
Source Title	Electrochimica acta. - : Elsevier - ISSN 0013-4686 Roč. 106, SEP2013 (2013), s. 43-48
Number of pages	6 s.
Publication form	Print - P
Language	eng - English
Country	GB - United Kingdom
Keywords	QUARTZ-CRYSTAL-MICROBALANCE ; SELF-ASSEMBLED MONOLAYERS ; BETA-SHEET PEPTIDES
Subject RIV	BO - Biophysics
R&D Projects	GAP301/11/2055 GA ČR - Czech Science Foundation (CSF)
Institutional support	BFU-R - RVO:68081707
UT WOS	000323192400005
DOI	10.1016/j.electacta.2013.05.057
Annotation	The interfacial behavior of the model amyloid peptide octamer YYKLVFFC (peptide 1) and two other amyloid peptides YEVHHQKLVFF (peptide 2) and KKLVFFA (peptide 3) at the metal aqueous solution interface was studied by voltammetric and constant current chronopotentiometric stripping (CPS). All three peptides are adsorbed in a wide potential range and exhibit different interfacial organizations depending on the electrode potential. At the least negative potentials, chemisorption of peptide 1 occurs through the formation of a metal-sulfur bond. This bond is broken close to -0.6V. The peptide undergoes self-association at more negative potentials, leading to the formation of a "pit" characteristic of a 2D condensed film. Under the same conditions the other peptides do not produce such a pit.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2014

Number of the records: 1