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Viability, longevity, and egg production of Drosophila melanogaster are regulated by the miR-282 microDNA

SYSNO ASEP	0422599
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Viability, longevity, and egg production of Drosophila melanogaster are regulated by the miR-282 microDNA
Author(s)	Vilmos, P. (HU) Bujna, Á. (HU) Szuperák, M. (AU) Havelda, Z. (HU) Várallyay, É. (HU) Szabad, J. (HU) Kučerová, Lucie (BC-A)_{RID, ORCID} Somogyi, K. (DE) Kristó, I. (HU) Lukácsovich, T. (US) Jankovics, F. (HU) Henn, L. (HU) Erdélyi, M. (HU)
Number of authors	13
Source Title	Genetics. - : Genetics Society of America - ISSN 0016-6731 Roč. 195, č. 2 (2013), s. 469-480
Number of pages	12 s.
Language	eng - English
Country	US - United States
Keywords	Drosophila melanogaster
Subject RIV	ED - Physiology
Institutional support	BC-A - RVO:60077344
UT WOS	000325286200016
EID SCOPUS	84884946495
DOI	10.1534/genetics.113.153585
Annotation	The first microRNAs were discovered some 20 years ago, but only a small fraction of the microRNA-encoding genes have been described in detail yet. Here we report the molecular analysis of a computationally predicted Drosophila melanogaster microRNA gene, mir-282. We show that the mir-282 gene is the source of a 4.9-kb-long primary transcript with a 5' cap and a 3'-poly(A) sequence and a mature microRNA of similar to 25 bp. Our data strongly suggest the existence of an independent mir-282 gene conserved in holometabolic insects. We give evidence that the mir-282 locus encodes a functional transcript that influences viability, longevity, and egg production in Drosophila. We identify the nervous system-specific adenylate cyclase (rutabaga) as a target of miR-282 and assume that one of the main functions of mir-282 is the regulation of adenylate cyclase activity in the nervous system during metamorphosis.
Workplace	Biology Centre (since 2006)
Contact	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Year of Publishing	2014

Number of the records: 1