Number of the records: 1
Transmembrane adaptor proteins in the high-affinity IgE receptor signaling
- 1.
SYSNO ASEP 0399709 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Transmembrane adaptor proteins in the high-affinity IgE receptor signaling Author(s) Dráber, Petr (UMG-J) RID
Hálová, Ivana (UMG-J) RID, ORCID
Levi-Schaffer, F. (IL)
Dráberová, Lubica (UMG-J) RIDSource Title Frontiers in Immunology. - : Frontiers Media - ISSN 1664-3224
Roč. 2, 11.1. (2012), s. 95Number of pages 11 s. Publication form Online - E Language eng - English Country CH - Switzerland Keywords IgE receptor ; LAT/LAT1 ; LAX ; NTAL/Lab/LAT2 ; PAG/Cbp ; mast cells ; plasma membrane ; transmembrane adaptor proteins Subject RIV EB - Genetics ; Molecular Biology R&D Projects 1M0506 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA301/09/1826 GA ČR - Czech Science Foundation (CSF) GAP302/10/1759 GA ČR - Czech Science Foundation (CSF) KAN200520701 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) Institutional support UMG-J - RVO:68378050 CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000209501200011 DOI 10.3389/fimmu.2011.00095 Annotation Aggregation of the high-affinity IgE receptor (FcεRI) initiates a cascade of signaling events leading to release of preformed inflammatory and allergy mediators and de novo synthesis and secretion of cytokines and other compounds. The first biochemically well defined step of this signaling cascade is tyrosine phosphorylation of the FcεRI subunits by Src family kinase Lyn, followed by recruitment and activation of spleen tyrosine kinase (Syk). Activity of Syk is decisive for the formation of multicomponent signaling assemblies, the signalosomes, in the vicinity of the receptors. Formation of the signalosomes is dependent on the presence of transmembrane adaptor proteins (TRAPs). These proteins are characterized by a short extracellular domain, a single transmembrane domain, and a cytoplasmic tail with various motifs serving as anchors for cytoplasmic signaling molecules. In mast cells five TRAPs have been identified [linker for activation of T cells (LAT), non-T cell activation linker (NTAL), linker for activation of X cells (LAX), phosphoprotein associated with glycosphingolipid-enriched membrane microdomains (PAG), and growth factor receptor-bound protein 2 (Grb2)-binding adaptor protein, transmembrane (GAPT)]; engagement of four of them (LAT, NTAL, LAX, and PAG) in FcεRI signaling has been documented. Here we discuss recent progress in the understanding of how TRAPs affect FcεRI-mediated mast cell signaling. The combined data indicate that individual TRAPs have irreplaceable roles in important signaling events such as calcium response, degranulation, cytokines production, and chemotaxis. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2014
Number of the records: 1