Number of the records: 1

Photodynamic effects of 31 different phthalocyanines on a human keratinocyte cell line

SYSNO ASEP	0398140
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Photodynamic effects of 31 different phthalocyanines on a human keratinocyte cell line
Author(s)	Jančula, Daniel (BU-J)_RID Maršálek, Blahoslav (BU-J)_{ORCID, SAI} Babica, Pavel (BU-J)_{RID, ORCID}
Number of authors	3
Source Title	Chemosphere. - : Elsevier - ISSN 0045-6535 Roč. 93, č. 6 (2013), s. 870-874
Number of pages	5 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	phthalocyanines ; photodynamics ; toxicity
Subject RIV	EF - Botanics
R&D Projects	TA01010356 GA TA ČR - Technology Agency of the Czech Republic (TA ČR)
Institutional support	BU-J - RVO:67985939
UT WOS	000326857900004
DOI	10.1016/j.chemosphere.2013.05.032
Annotation	We have found light dependent toxicity of different groups of Pcs on HaCaT cells. The most pronounced toxicity was elicited by Pcs with high positive densities at peripheral parts of substituent groups under illumination by white light. EC50 values for HaCaT cells are an order or two orders of magnitude higher than concentrations considered for management purposes in aquaculture, which indicate the safety of such applications for human or animal skin cells after the exposition. Nevertheless, more research including risk assessment should be done to confirm such conclusions.
Workplace	Institute of Botany
Contact	Martina Bartošová, martina.bartosova@ibot.cas.cz, ibot@ibot.cas.cz, Tel.: 271 015 242 ; Marie Jakšová, marie.jaksova@ibot.cas.cz, Tel.: 384 721 156-8
Year of Publishing	2014

Number of the records: 1