Enantioseparation of newly synthesized acyclic nucleoside phosphonates-based antivirals by capillary electrophoresis using cyclodextrins as chiral selectors

Šolínová, Veronika; Kaiser, Martin Maxmilian; Lukáč, Miloš; Janeba, Zlatko; Kašička, Václav

Number of the records: 1

Enantioseparation of newly synthesized acyclic nucleoside phosphonates-based antivirals by capillary electrophoresis using cyclodextrins as chiral selectors

1.

SYSNO ASEP	0398135
Document Type	C - Proceedings Paper (int. conf.)
R&D Document Type	The record was not marked in the RIV
Title	Enantioseparation of newly synthesized acyclic nucleoside phosphonates-based antivirals by capillary electrophoresis using cyclodextrins as chiral selectors
Author(s)	Šolínová, Veronika (UOCHB-X)_{RID, ORCID} Kaiser, Martin Maxmilian (UOCHB-X)_{RID, ORCID} Lukáč, Miloš (UOCHB-X) Janeba, Zlatko (UOCHB-X)_{RID, ORCID} Kašička, Václav (UOCHB-X)_{RID, ORCID}
Number of authors	5
Source Title	Analytické metódy a zdravie človeka. 19. medzinárodná konferencia. - Bratislava : Slovenská vákuová spoločnosť, 2013 / Bodor R. ; Okenicová L. ; Staňová A. - ISBN 978-80-971179-1-7
Pages	s. 245-247
Number of pages	3 s.
Publication form	Print - P
Action	Analytické metódy a zdravie človeka. Medzinárodná konferencia /19./
Event date	24.06.2013-27.06.2013
VEvent location	Rajecké Teplice
Country	SK - Slovakia
Event type	EUR
Language	eng - English
Country	SK - Slovakia
Keywords	acyclic nucleoside phosphonates ; chiral analysis ; capillary electrophoresis
Subject RIV	CB - Analytical Chemistry, Separation
R&D Projects	GAP206/12/0453 GA ČR - Czech Science Foundation (CSF)
	GA13-17224S GA ČR - Czech Science Foundation (CSF)
	VG20102015046 GA MV - Ministry of Interior (MV)
Institutional support	UOCHB-X - RVO:61388963
Annotation	Capillary electrophoresis (CE) methods were developed for chiral separation and enantiopurity control of six newly synthesized R,S-enantiomers of acyclic nucleoside phosphonates (ANPs)-based potential antivirals containing ((3-hydroxypropan-2-yl)-1H-1,2,3-triazol-4-yl)phosphonic acid moiety, 2 (phosphonomethoxy)propanoic acid or its diisopropyl derivative as side chains of adenine, guanine, diaminopurine, uracil and 5-bromouracil nucleobases, using sodium tetraborate, pH 9.6-10.3, or Tris-phosphate, pH 2.2, as background electrolytes and beta-cyclodextrin or quaternary-ammonium-beta-cyclodextrin as chiral selectors.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2014

Number of the records: 1