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Caspase-7 participates in differentiation of cells forming dental hard tissues
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SYSNO ASEP 0397909 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Caspase-7 participates in differentiation of cells forming dental hard tissues Author(s) Matalová, Eva (UZFG-Y) RID
Lesot, H. (FR)
Švandová, Eva (UZFG-Y) RID, ORCID
Vanden Berghe, T. (BE)
Sharpe, P. T. (GB)
Healy, C. (GB)
Vandenabeele, P. (BE)
Tucker, A. S. (GB)Source Title Development Growth & Differentiation - ISSN 0012-1592
Roč. 55, č. 5 (2013), s. 615-621Number of pages 7 s. Publication form Print - P Language eng - English Country JP - Japan Keywords ameloblast ; apoptosis ; caspase Subject RIV EB - Genetics ; Molecular Biology R&D Projects GAP304/11/1418 GA ČR - Czech Science Foundation (CSF) Institutional support UZFG-Y - RVO:67985904 UT WOS 000320470700003 DOI 10.1111/dgd.12066 Annotation Apoptosis during tooth development appears dependent on the apoptotic executioner caspase-3, but not caspase-7. Instead, activated caspase-7 has been found in differentiated odontoblasts and ameloblasts, where it does not correlate with apoptosis. To further investigate these findings, the mouse incisor was used as a model. Analysis of caspase-7-deficient mice revealed a significant thinner layer of hard tissue in the adult incisor. Micro computed tomography scan confirmed this decrease in mineralized tissues. These data strongly suggest that caspase-7 might be directly involved in functional cell differentiation and regulation of the mineralization of dental matrices. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2014
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