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The role of mesenchymal stromal cells in spinal cord injury, regenerative medicine and possible clinical applications
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SYSNO ASEP 0397685 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The role of mesenchymal stromal cells in spinal cord injury, regenerative medicine and possible clinical applications Author(s) Forostyak, Serhiy (UEM-P) RID, ORCID
Jendelová, Pavla (UEM-P) RID, ORCID
Syková, Eva (UEM-P) RIDNumber of authors 3 Source Title Biochimie. - : Elsevier - ISSN 0300-9084
Roč. 95, č. 12 (2013), s. 2257-2270Number of pages 14 s. Language eng - English Country FR - France Keywords stem cells ; regeneration ; clinical trials Subject RIV FH - Neurology R&D Projects GA13-00939S GA ČR - Czech Science Foundation (CSF) GAP304/10/0320 GA ČR - Czech Science Foundation (CSF) GAP304/11/0189 GA ČR - Czech Science Foundation (CSF) GBP304/12/G069 GA ČR - Czech Science Foundation (CSF) EE2.3.30.0018 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UEM-P - RVO:68378041 UT WOS 000327805400008 EID SCOPUS 84887820691 DOI 10.1016/j.biochi.2013.08.004 Annotation In the review the progress made in the cell-based therapy of spinal cord injury is discussed. An emphasis has been placed on the application of adult mesenchymal stromal cells (MSCs). The latest and most significant results from in vitro and in vivo research focusing on the regenerative/neuroprotective properties of MSCs were reviewedCorrelation of the effect of MSCs with the pathological events that are taking place in the nervous tissue after SCI was done. The results from preclinical and clinical trials involving different routes of MSC application into patients with neurological disorders of the spinal cord were discussed. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2014
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