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Evaluation of tumor suppressor gene expressions and aberrant methylation in the colon of cancer-induced rats: a pilot study
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SYSNO ASEP 0397116 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Evaluation of tumor suppressor gene expressions and aberrant methylation in the colon of cancer-induced rats: a pilot study Author(s) Vymetálková, Veronika (UEM-P) RID
Vannucci, Luca (MBU-M) RID, ORCID
Korenková, Vlasta (BTO-N) RID
Procházka, Pavel (UEM-P) RID
Slyšková, Jana (UEM-P) RID
Vodičková, Ludmila (UEM-P) RID
Rusňáková, Vendula (BTO-N)
Bielik, Ludovít (UEM-P)
Burocziová, Monika (MBU-M)
Rossmann, Pavel (MBU-M)
Vodička, Pavel (UEM-P) RIDNumber of authors 11 Source Title Molecular Biology Reports. - : Springer - ISSN 0301-4851
Roč. 40, č. 10 (2013), s. 5921-5929Number of pages 9 s. Language eng - English Country NL - Netherlands Keywords colorectal cancer ; rats ; mRNA expression Subject RIV EB - Genetics ; Molecular Biology Subject RIV - cooperation Institute of Botany - Genetics ; Molecular Biology
Institute of Microbiology - Genetics ; Molecular BiologyR&D Projects IAA500200917 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GPP304/11/P715 GA ČR - Czech Science Foundation (CSF) Institutional support MBU-M - RVO:61388971 ; UEM-P - RVO:68378041 ; BTO-N - RVO:86652036 CEZ AV0Z50390703 - UEM-P (2007-2013) AV0Z50520701 - BTO-N (2007-2013) AV0Z50390512 - UEM-P (2005-2011) UT WOS 000325948400042 EID SCOPUS 84892694613 DOI 10.1007/s11033-013-2699-8 Annotation The aim of this pilot study was to analyze expression profile and promoter methylation status of important tumor suppressor and DNA repair genes in the early stages of experimentally induced colorectal carcinogenesis. Rats were treated with azoxymethane (AOM), dextran sodium sulphate (DSS) or with their combination, and sacrificed 1 or 4 months post-treatment period. Present data suggest that down-regulation of Apc and MMR genes are prerequisite for the development of CRC. In this study we addressed for the first time early functional alterations of tumor suppressor genes with underlying epigenetic mechanisms in experimentally induced CRC in rats. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2014
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