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Modulation of synaptic depression of the calyx of Held synapse by GABAB receptors and spontaneous activity
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SYSNO ASEP 0397105 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Modulation of synaptic depression of the calyx of Held synapse by GABAB receptors and spontaneous activity Author(s) Wang, T. (NL)
Rusu, S. I. (NL)
Hrušková, Bohdana (UEM-P)
Tureček, Rostislav (UEM-P) RID, ORCID
Borst, J. G. (NL)Number of authors 5 Source Title Journal of Physiology. - : Wiley - ISSN 0022-3751
Roč. 591, č. 19 (2013), s. 4877-4894Number of pages 18 s. Language eng - English Country GB - United Kingdom Keywords GABAB ; synaptic transmission ; auditory Subject RIV FH - Neurology R&D Projects GAP303/11/0131 GA ČR - Czech Science Foundation (CSF) Institutional support UEM-P - RVO:68378041 UT WOS 000325151600017 EID SCOPUS 84884984029 DOI 10.1113/jphysiol.2013.256875 Annotation The calyx of Held synapse of the medial nucleus of the trapezoid body is a giant axosomatic synapse in the auditory brainstem, which acts as a relay synapse showing large number of release sites with low release probability. We investigated the contribution of presynaptic GABAB receptors and spontaneous activity to release probability both in vivo and in vitro in young-adult mice. Our data thus suggest that spontaneous firing can tonically reduce release probability in vivo. In addition, our data show that the ambient GABA concentration in the auditory brainstem is too low to activate the GABAB receptor at the calyx of Held significantly, but that activation of GABAB receptors can reduce sound-evoked synaptic depression. key words (3): GABAB, synaptic transmission, auditory Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2014
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