Number of the records: 1

Interaction of the tick immune system with transmitted pathogens

SYSNO ASEP	0396807
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Interaction of the tick immune system with transmitted pathogens
Author(s)	Hajdušek, Ondřej (BC-A)_{RID, ORCID} Šíma, Radek (BC-A)_{RID, ORCID} Ayllón, N. (ES) Jalovecká, M. (CZ) Pernes, J. (CZ) de la Fuente, J. (ES) Kopáček, Petr (BC-A)_{RID, ORCID}
Source Title	Frontiers in Cellular and Infection Microbiology. - : Frontiers Media - ISSN 2235-2988 Roč. 3, Jul 2013 (2013), a26
Number of pages	15 s.
Publication form	Online - E
Language	eng - English
Country	CH - Switzerland
Keywords	Anaplasma ; Babesia ; Borrelia ; antimicrobial peptides ; innate immunity ; phagocytosis ; tick ; tick-borne diseases
Subject RIV	EC - Immunology
R&D Projects	GAP506/10/2136 GA ČR - Czech Science Foundation (CSF)
	GA13-11043S GA ČR - Czech Science Foundation (CSF)
	GP13-27630P GA ČR - Czech Science Foundation (CSF)
	GP13-12816P GA ČR - Czech Science Foundation (CSF)
	EE2.3.30.0032 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	BC-A - RVO:60077344
UT WOS	000324649500003
DOI	10.3389/fcimb.2013.00026
Annotation	Ticks are hematophagous arachnids transmitting a wide variety of pathogens including viruses, bacteria, and protozoans to their vertebrate hosts. The tick vector competence has to be intimately linked to the ability of transmitted pathogens to evade tick defense mechanisms encountered on their route through the tick body comprising midgut, hemolymph, salivary glands or ovaries. Tick innate immunity is, like in other invertebrates, based on an orchestrated action of humoral and cellular immune responses. The direct antimicrobial defense in ticks is accomplished by a variety of small molecules such as defensins, lysozymes or by tick-specific antimicrobial compounds such as microplusin/hebraein or 5.3-kDa family proteins. Phagocytosis of the invading microbes by tick hemocytes is likely mediated by the primordial complement-like system composed of thioester-containing proteins, fibrinogen-related lectins and convertase-like factors. Moreover, an important role in survival of the ingested microbes seems to be played by host proteins and redox balance maintenance in the tick midgut. Here, we summarize recent knowledge about the major components of tick immune system and focus on their interaction with the relevant tick-transmitted pathogens, represented by spirochetes (Borrelia), rickettsiae (Anaplasma), and protozoans (Babesia). Availability of the tick genomic database and feasibility of functional genomics based on RNA interference greatly contribute to the understanding of molecular and cellular interplay at the tick-pathogen interface and may provide new targets for blocking the transmission of tick pathogens.
Workplace	Biology Centre (since 2006)
Contact	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Year of Publishing	2014

Number of the records: 1