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The Dynamics of Supernumerary Tooth Development Are Differentially Regulated by Sprouty Genes

SYSNO ASEP	0396249
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	The Dynamics of Supernumerary Tooth Development Are Differentially Regulated by Sprouty Genes
Author(s)	Lagronová-Churavá, Svatava (UEM-P) Špoutil, František (UEM-P) Vojtěchová, Simona (UEM-P) Lesot, H. (FR) Peterka, Miroslav (UEM-P)_RID Klein, O. D. (US) Peterková, Renata (UEM-P)_RID
Number of authors	7
Source Title	Journal of Experimental Zoology Part B: Molecular and Developmental Evolution Additional Title Information. - : Wiley - ISSN 1552-5007 Roč. 320, č. 5 (2013), s. 307-320
Number of pages	14 s.
Language	eng - English
Country	US - United States
Keywords	embryonic signaling center ; morphogenesis ; mouse odontogenesis
Subject RIV	EA - Cell Biology
R&D Projects	GAP305/12/1766 GA ČR - Czech Science Foundation (CSF)
Institutional support	UEM-P - RVO:68378041
UT WOS	000320170600006
EID SCOPUS	84879043339
DOI	10.1002/jez.b.22502
Annotation	We investigated the participation of two diastemal rudiments (MS and R2) in supernumerary tooth development in Spry2 and Spry4 mutant mice by comparing morphogenesis, proliferation, apoptosis, size and Shh expression in the dental epithelium of MS and R2 rudiments and the first molar. Increased proliferation and decreased apoptosis were found in MS and R2 at embryonic day (ED) 12.5 and 13.5 in Spry2-/- embryos. Apoptosis was also decreased in both rudiments in Spry4-/- embryos, but the proliferation was lower (similar to WTmice), and supernumerary tooth development was accelerated, exhibiting a cap stage by ED13.5. Majority of the supernumerary tooth primordia degenerated prenatally, resulting in a low percentage of supernumerary teeth in adults.
Workplace	Institute of Experimental Medicine
Contact	Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
Year of Publishing	2014

Number of the records: 1