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Erythropoiesis- and Thrombopoiesis-Characterizing Parameters in Adenosine A(3) Receptor Knock-Out Mice

SYSNO ASEP	0394862
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Erythropoiesis- and Thrombopoiesis-Characterizing Parameters in Adenosine A(3) Receptor Knock-Out Mice
Author(s)	Hofer, Michal (BFU-R)_{RID, ORCID} Pospíšil, Milan (BFU-R) Dušek, L. (CZ) Hoferová, Zuzana (BFU-R)_RID Weiterová, Lenka (BFU-R)_RID
Number of authors	6
Source Title	Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408 Roč. 62, č. 3 (2013), s. 305-311
Number of pages	7 s.
Publication form	Online - E
Language	eng - English
Country	CZ - Czech Republic
Keywords	ELEVATING EXTRACELLULAR ADENOSINE ; COLONY-STIMULATING FACTOR ; HEMATOPOIETIC PROGENITOR CELLS
Subject RIV	BO - Biophysics
R&D Projects	GAP303/11/0128 GA ČR - Czech Science Foundation (CSF)
Institutional support	BFU-R - RVO:68081707
UT WOS	000321322900009
Annotation	Influence of the regulatory system mediated by adenosine A(3) receptors on the functioning of erythropoiesis and thrombopoiesis was studied by means of evaluation of the numbers and attributes of peripheral blood erythrocytes and platelets, as well as of erythroid bone marrow progenitor cells in adenosine A(3) receptor knock-out (Adora3(tm1Jbsn)/Adora3(tm1Jbsn), A(3)AR((-/-))) mice and their wild-type C57BL/6 counterparts, both males and females. Minor but statistically significant disturbances in the properties of erythrocytes, namely in the parameters of mean erythrocyte volume and mean erythrocyte hemoglobin were observed in A(3)AR((-/-)) mice.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2014

Number of the records: 1