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Selective elimination/RNAi silencing of FMRF-related peptides and their receptors decreases the locomotor activity in Drosophila melanogaster
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SYSNO ASEP 0394182 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Selective elimination/RNAi silencing of FMRF-related peptides and their receptors decreases the locomotor activity in Drosophila melanogaster Author(s) Kiss, B. (HU)
Szlanka, T. (HU)
Zvara, Á. (HU)
Žurovec, Michal (BC-A) RID, ORCID
Šerý, Michal (BC-A) ORCID
Kakaš, Štefan (BC-A)
Ramasz, B. (HU)
Hegedűs, Z. (HU)
Lukacsovich, T. (US)
Puskás, L. (HU)
Fónagy, A. (HU)
Kiss, I. (HU)Number of authors 12 Source Title General and Comparative Endocrinology. - : Elsevier - ISSN 0016-6480
Roč. 191, SEP 15 (2013), s. 137-145Number of pages 9 s. Language eng - English Country US - United States Keywords Drosophila melanogaster ; FMRF-related peptides ; G protein-coupled receptors Subject RIV EB - Genetics ; Molecular Biology Institutional support BC-A - RVO:60077344 UT WOS 000323870400015 EID SCOPUS 84880386491 DOI 10.1016/j.ygcen.2013.05.023 Annotation Drosophila FMRF-related neuropeptides are functionally unrelated peptides targeting different organs, with different effective thresholds, time-course and expression patterns. They were all suggested to have an effect on the locomotor activity of Drosophila adults. We prepared RNAi knockdowns of the peptides and their specific receptor genes as well as ablated FMRF-positive neurons by inducing apoptosis using the reaper (rpr) gene expression. We show that RNAi silencing of the FaRP and FaRP-receptor genes effectively decreased the startle-induced locomotor activity of flies. Consistantly, the ablation of FMRF-positive neurons by the RS8-Gal4 and/or RS17-Gal4 drivers also significantly decreased fly locomotion. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2014 Electronic address http://www.sciencedirect.com/science/article/pii/S0016648013002621
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