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Classification of mitocans, anti-cancer drugs acting on mitochondria
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SYSNO ASEP 0393079 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Classification of mitocans, anti-cancer drugs acting on mitochondria Author(s) Neužil, Jiří (BTO-N) RID
Dong, L. F. (AU)
Rohlena, Jakub (BTO-N) RID, ORCID
Truksa, Jaroslav (BTO-N) RID, ORCID
Ralph, S. J. (AU)Source Title Mitochondrion. - : Elsevier - ISSN 1567-7249
Roč. 13, č. 3 (2013), s. 199-208Number of pages 10 s. Language eng - English Country GB - United Kingdom Keywords Mitocans ; Anti-cancer therapeutics ; Classification Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000317445700007 DOI 10.1016/j.mito.2012.07.112 Annotation Mitochondria have emerged as an intriguing target for anti-cancer drugs, inherent to vast majority if not all types of tumours. Drugs that target mitochondria and exert anti-cancer activity have become a focus of recent research due to their great clinical potential (which has not been harnessed thus far). The exceptional potential of mitochondria as a target for anti-cancer agents has been reinforced by the discouraging finding that even turnouts of the same type from individual patients differ in a number of mutations. This is consistent with the idea of personalised therapy, an elusive goal at this stage, in line with the notion that tumours are unlikely to be treated by agents that target only a single gene or a single pathway. This endows mitochondria, an invariant target present in all tumours, with an exceptional momentum. This train of thoughts inspired us to define a class of anti-cancer drugs acting by way of mitochondria 'destabilisation', termed 'mitocans'. In this communication, we define mitocans (many of which have been known for a long time) and classify them into several classes based on their molecular mode of action. We chose the targets that are of major importance from the point of view of their role in mitochondrial destabilisation by small compounds, some of which are now trialled as anti-cancer agents. The classification starts with targets at the surface of mitochondria and ending up with those in the mitochondrial matrix. The purpose of this review is to present in a concise manner the classification of compounds that hold a considerable promise as potential anti-cancer drugs. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2014
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