Number of the records: 1
Adverse effect of tetracycline and doxycycline on testicular tissue and sperm parameters in CD1 outbred mice
- 1.
SYSNO ASEP 0391729 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Adverse effect of tetracycline and doxycycline on testicular tissue and sperm parameters in CD1 outbred mice Author(s) Elzeinová, Fatima (BTO-N) RID
Pěknicová, Jana (BTO-N) RID
Děd, Lukáš (BTO-N) RID
Kubátová, Alena (BTO-N) RID
Margaryan, Hasmik (BTO-N) RID
Dorosh, Andriy (BTO-N) RID
Makovický, P. (CZ)
Rajmon, R. (CZ)Number of authors 8 Source Title Experimental and Toxicologic Pathology. - : Elsevier - ISSN 0940-2993
Roč. 65, Sep (2013), s. 911-917Number of pages 7 s. Language eng - English Country DE - Germany Keywords Tetracycline ; Doxycycline ; Testes ; Sperm ; Apoptosis ; Puberty Subject RIV DN - Health Impact of the Environment Quality R&D Projects 1M06011 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA523/09/1793 GA ČR - Czech Science Foundation (CSF) GAP503/12/1834 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000322929800024 Annotation Tetracycline and doxycycline are commonly used antibiotics in acne treatment during puberty in humans. The long-term effect of these antibiotics on male reproductive tract development has not been fully elucidated. For this reason we tested the effect of antibiotics on the reproductive parameters of mice males during puberty with the therapeutic dose used in humans, and with lower and higher doses. The outbred mouse strain CD1 with higher heterozygosity was exposed for 14 days at puberty. Adult males at the age of 70 days were used for the measurements. We observed a significant decrease in anogenital distance and thickness of the seminiferous epithelium in the treated animals. Pathological changes in the testes had an impact on sperm quality; a higher number of sperm positively stained with Annexin V and TUNEL and a lower number of acrosome-intact sperm was detected. In conclusion, the treatment of male mice with antibiotics in puberty led to long-lasting effects on reproductive organs and spermatozoa in adult males. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2014
Number of the records: 1