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In Situ Monitoring of Asymmetric Transfer Hydrogenation of Imines Using NMR Spectrometry
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SYSNO ASEP 0390839 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title In Situ Monitoring of Asymmetric Transfer Hydrogenation of Imines Using NMR Spectrometry Author(s) Václavík, J. (CZ)
Pecháček, J. (CZ)
Přech, J. (CZ)
Kuzma, Marek (MBU-M) ORCID, RID
Kačer, P. (CZ)
Červený, L. (CZ)Source Title Chemické listy. - : Česká společnost chemická - ISSN 0009-2770
Roč. 106, č. 3 (2012), s. 206-210Number of pages 5 s. Language eng - English Country CZ - Czech Republic Keywords NMR Spectrometry ; asymmetric transfer hydrogenation Subject RIV CE - Biochemistry R&D Projects GA104/09/1497 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000301911700009 Annotation Three methods for determination of enantioselectivity of asymmetric transfer hydrogenation of imines are presented: direct NMR observation of diastereomeric reduction products of a chiral imine, chiral solvation with Pirkle' s alcohol, (-)-(1R)-1-(9-anthryl)-2,2,2-trifluoroethan-1-ol and precolumn derivatization with (-)-(1R)-menthyl chloroformate followed by GC analysis on a non-chiral column of the resulting diastereomeric carbamates Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2013
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