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Effects of Combined Endothelin A Receptor and Renin-Angiotensin System Blockade on the Course of End-Organ Damage in 5/6 Nephrectomized Ren-2 Hypertensive Rats
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SYSNO ASEP 0390670 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Effects of Combined Endothelin A Receptor and Renin-Angiotensin System Blockade on the Course of End-Organ Damage in 5/6 Nephrectomized Ren-2 Hypertensive Rats Author(s) Vaněčková, Ivana (FGU-C) RID, ORCID
Kujal, P. (CZ)
Husková, Z. (CZ)
Vaňourková, Z. (CZ)
Vernerová, Z. (CZ)
Čertíková - Chábová, V. (CZ)
Škaroupková, P. (CZ)
Kramer, H. J. (DE)
Tesař, V. (CZ)
Červenka, L. (CZ)Source Title Kidney & Blood Pressure Research. - : Karger - ISSN 1420-4096
Roč. 35, č. 5 (2012), s. 382-392Number of pages 11 s. Language eng - English Country CH - Switzerland Keywords 5/6 nephrectomy ; Endothelin receptor type A ; AT1 receptor blocker ; end-organ damage ; hypertension Subject RIV FA - Cardiovascular Diseases incl. Cardiotharic Surgery CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000305594600011 DOI 10.1159/000336823 Annotation The additive effect of endothelin-1 blockade to renin-angiotensin blockade was evaluated in rats with ablation nephrectomy. While RAS blockade normalized blood pressure (BP), improved survival, decreased cardiac hypertrophy and proteinuria as well as tissue angiotensin II and ET-1 levels, ETA receptor blockade only partially improved survival rate, reduced BP, attenuated the development of cardiac hypertrophy and transiently reduced proteinuria. No additive cardio- and renoprotective effects of ETA and RAS blockade were noted at the end of the study suggesting that the RAS system is the main target for antihypertensive treatment in models with inappropriately activated RAS Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2013
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