Effect of fluoxetine and adenosine receptor NECA agonist on G alpha q/11 protein of C6 glioma cells
1.
SYSNO ASEP
0390643
Document Type
J - Journal Article
R&D Document Type
Journal Article
Subsidiary J
Článek ve WOS
Title
Effect of fluoxetine and adenosine receptor NECA agonist on G alpha q/11 protein of C6 glioma cells
Author(s)
Kovářů, H. (CZ) Kovářů, F. (CZ) Lisá, Věra (FGU-C)
Source Title
Neuroendocrinology Letters
- ISSN 0172-780X
Roč. 33, č. 6 (2012), s. 614-618
Number of pages
5 s.
Language
eng - English
Country
SE - Sweden
Keywords
C6 glioma cells ; SSRI antidepressant ; G alpha q/11 signalling ; G protein coupled receptor
Subject RIV
ED - Physiology
Institutional support
FGU-C - RVO:67985823
UT WOS
000312175300009
Annotation
In C6 glioma cells, we studied acute administration of SSRI antidepressants - fluoxetine, sertraline and citalopram. We used immunochemical estimation (ELISA) of the main types of G-protein alpha subunits from isolated membranes of C6 glioma cells. We also estimated effect of NECA agonist on fluoxetine induced signalling via 1,4,5 IP3 and its levels. Presented data are first findings about adenosine receptor interaction with fluoxetine signalling. Thus in vitro studies contribute to the clarification of the molecular basis of antidepressant action
