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Irradiated stem cells and ageing of the haematopoietic system
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SYSNO ASEP 0390349 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Irradiated stem cells and ageing of the haematopoietic system Author(s) Vávrová, J. (CZ)
Šinkorová, Z. (CZ)
Řezáčová, M. (CZ)
Tichý, Adam (ASU-R)
Filip, S. (CZ)
Mokrý, J. (CZ)
Lukášová, Emilie (BFU-R) RID, ORCIDNumber of authors 7 Source Title Radiation and Environmental Biophysics - ISSN 0301-634X
Roč. 51, č. 2 (2012), s. 205-213Number of pages 9 s. Publication form Print - P Language eng - English Country US - United States Keywords Irradiation ; Ageing of haematopoiesis ; Anaemia Subject RIV BO - Biophysics Institutional support BFU-R - RVO:68081707 CEZ AV0Z50040702 - BFU-R (2007-2013) UT WOS 000303464400010 DOI 10.1007/s00411-012-0401-5 Annotation In the work presented here, changes in haematopoiesis of mice (B6129SF2/J) were studied 1 year after their whole-body exposure to a dose of 7 Gy (72% of mice survived). The irradiated mice were compared with non-irradiated younger (4 months of age) and older (16 months of age) mice. There was a significant increase in the relative abundance of primitive stem cells with long-term capability of the haematopoiesis recovery lin(-)/Sca-1(+)/CD117(+)/CD34(-) in the bone marrow of mice aged 16 months (irradiated and non-irradiated) compared with those aged 4 months. In terms of the ability to respond to further whole-body irradiation at a dose of 1 Gy, the presence of gamma H2A.X foci was studied in lin(-) bone marrow cells. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2013
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