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Celiac disease markers in patients with liver diseases: A single center large scale screening study
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SYSNO ASEP 0388690 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Celiac disease markers in patients with liver diseases: A single center large scale screening study Author(s) Drastich, P. (CZ)
Honsová, E. (CZ)
Lodererová, A. (CZ)
Jarešová, M. (CZ)
Pekáriková, Aneta (MBU-M)
Hoffmanová, I. (CZ)
Tučková, Ludmila (MBU-M) RID
Tlaskalová-Hogenová, Helena (MBU-M) RID, ORCID
Špičák, J. (CZ)
Sánchez, Daniel (MBU-M) RIDSource Title World Journal of Gastroenterology - ISSN 1007-9327
Roč. 18, č. 43 (2012), s. 6255-6262Number of pages 8 s. Language eng - English Country CN - China Keywords Tissue transglutaminase ; Anti-tissue transglutaminase antibodies ; Autoimmune liver diseases Subject RIV EC - Immunology R&D Projects IAA500200709 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GA310/07/0414 GA ČR - Czech Science Foundation (CSF) Institutional support MBU-M - RVO:61388971 UT WOS 000311522700011 DOI 10.3748/wjg.v18.i43.6255 Annotation AIM: To study the coincidence of celiac disease, we tested its serological markers in patients with various liver diseases.Large-scale screening of serum antibodies against tissue transglutaminase (tTG), and deamidated gliadin using enzyme-linked immunosorbent assay and serum antibodies against endomysium using immunohistochemistry, in patients with various liver diseases (n = 962) and patients who underwent liver transplantation (OLTx, n = 523) was performed. The expression of tTG in liver tissue samples of patients simultaneously suffering from celiac disease and from various liver diseases using immunohistochemistry was carried out. The final diagnosis of celiac disease was confirmed by histological analysis of small-intestinal biopsy Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2013
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