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Transcriptional regulation of the operon encoding stress-responsive ECF sigma factor SigH and its anti-sigma factor RshA, and control of its regulatory network in Corynebacterium glutamicum
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SYSNO ASEP 0387740 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Transcriptional regulation of the operon encoding stress-responsive ECF sigma factor SigH and its anti-sigma factor RshA, and control of its regulatory network in Corynebacterium glutamicum Author(s) Busche, T. (DE)
Šilar, Radoslav (MBU-M)
Pičmanová, Martina (MBU-M)
Pátek, Miroslav (MBU-M) RID, ORCID
Kalinowski, J. (DE)Source Title BMC Genomics. - : BioMed Central - ISSN 1471-2164
Roč. 13, č. 445 (2012), s. 445-464Number of pages 20 s. Language eng - English Country GB - United Kingdom Keywords Corynebacterium glutamicum ; ECF sigma factor ; Anti-sigma factor Subject RIV EE - Microbiology, Virology R&D Projects GC204/09/J015 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000310708800001 DOI 10.1186/1471-2164-13-445 Annotation Background: The expression of genes in Corynebacterium glutamicum, a Gram-positive non-pathogenic bacterium used mainly for the industrial production of amino acids, is regulated by seven different sigma factors of RNA polymerase, including the stress-responsive ECF-sigma factor SigH. The sigH gene is located in a gene cluster together with the rshA gene, putatively encoding an anti-sigma factor. The aim of this study was to analyze the transcriptional regulation of the sigH and rshA gene cluster and the effects of RshA on the SigH regulon, in order to refine the model describing the role of SigH and RshA during stress response Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2013
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