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CD36 Protein Influences Myocardial Ca2+ Homeostasis and Phospholipid Metabolism CONDUCTION ANOMALIES IN CD36-DEFICIENT MICE DURING FASTING
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SYSNO ASEP 0387525 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title CD36 Protein Influences Myocardial Ca2+ Homeostasis and Phospholipid Metabolism CONDUCTION ANOMALIES IN CD36-DEFICIENT MICE DURING FASTING Author(s) Pietka, T. A. (US)
Sulkin, M.S. (US)
Kuda, Ondřej (FGU-C) RID, ORCID, SAI
Wang, W. (US)
Zhou, D. (US)
Yamada, K. A. (US)
Yang, K. (US)
Su, X. (US)
Gross, R. W. (US)
Nerbonne, J. M. (US)
Efimov, I. R. (US)
Abumrad, N. A. (US)Source Title Journal of Biological Chemistry. - : Elsevier - ISSN 0021-9258
Roč. 287, č. 46 (2012), s. 38901-38912Number of pages 12 s. Language eng - English Country US - United States Keywords calcium ; cyclic AMP (cAMP) ; heart ; phospholipid ; phospholipid metabolism ; polyunsaturated fatty acids ; CD36 deficiency ; SERCA2a ; sudden death Subject RIV ED - Physiology Institutional support FGU-C - RVO:67985823 UT WOS 000310982800046 DOI 10.1074/jbc.M112.413609 Annotation Myocardial function during fasting was examined in wild-type and CD36−/− mice. CD36−/− mice have abnormalities of myocardial Ca2+, phospholipid composition, and cAMP levels and manifest electrical anomalies during fasting. Conclusion: CD36 influences myocardial adaptation by impacting Ca2+ dynamics and phospholipid metabolism. Significance: Inter-dependence of lipid metabolism and Ca2+ homeostasis can contribute to cardiac dysfunction during metabolic stress Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2013
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