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CD36 Protein Influences Myocardial Ca2+ Homeostasis and Phospholipid Metabolism CONDUCTION ANOMALIES IN CD36-DEFICIENT MICE DURING FASTING

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    SYSNO ASEP0387525
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleCD36 Protein Influences Myocardial Ca2+ Homeostasis and Phospholipid Metabolism CONDUCTION ANOMALIES IN CD36-DEFICIENT MICE DURING FASTING
    Author(s) Pietka, T. A. (US)
    Sulkin, M.S. (US)
    Kuda, Ondřej (FGU-C) RID, ORCID
    Wang, W. (US)
    Zhou, D. (US)
    Yamada, K. A. (US)
    Yang, K. (US)
    Su, X. (US)
    Gross, R. W. (US)
    Nerbonne, J. M. (US)
    Efimov, I. R. (US)
    Abumrad, N. A. (US)
    Source TitleJournal of Biological Chemistry - ISSN 0021-9258
    Roč. 287, č. 46 (2012), s. 38901-38912
    Number of pages12 s.
    Languageeng - English
    CountryUS - United States
    Keywordscalcium ; cyclic AMP (cAMP) ; heart ; phospholipid ; phospholipid metabolism ; polyunsaturated fatty acids ; CD36 deficiency ; SERCA2a ; sudden death
    Subject RIVED - Physiology
    Institutional supportFGU-C - RVO:67985823
    UT WOS000310982800046
    DOI10.1074/jbc.M112.413609
    AnnotationMyocardial function during fasting was examined in wild-type and CD36−/− mice. CD36−/− mice have abnormalities of myocardial Ca2+, phospholipid composition, and cAMP levels and manifest electrical anomalies during fasting. Conclusion: CD36 influences myocardial adaptation by impacting Ca2+ dynamics and phospholipid metabolism. Significance: Inter-dependence of lipid metabolism and Ca2+ homeostasis can contribute to cardiac dysfunction during metabolic stress
    WorkplaceInstitute of Physiology
    ContactLucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
    Year of Publishing2013
Number of the records: 1