Number of the records: 1

Tropism ablation and stealthing of oncolytic adenovirus enhances systemic delivery to tumors and improves virotherapy of cancer

SYSNO ASEP	0384590
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Tropism ablation and stealthing of oncolytic adenovirus enhances systemic delivery to tumors and improves virotherapy of cancer
Author(s)	Green, N. K. (GB) Hale, A. (GB) Cawood, R. (GB) Illingworth, S. (GB) Herbert, C. (GB) Hermiston, T. (US) Šubr, Vladimír (UMCH-V)_{RID, ORCID} Ulbrich, Karel (UMCH-V)_RID van Rooijen, N. (NL) Seymour, L. W. (GB) Fisher, K. D. (GB)
Source Title	Nanomedicine. - : Future Medicine - ISSN 1743-5889 Roč. 7, č. 11 (2012), s. 1683-1695
Number of pages	13 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	clodronate liposomes ; polymer-coated adenovirus ; predosing strategy
Subject RIV	CD - Macromolecular Chemistry
R&D Projects	IAAX00500803 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
Institutional support	UMCH-V - RVO:61389013
CEZ	AV0Z40500505 - UMCH-V (2005-2011)
UT WOS	000311329700013
DOI	10.2217/NNM.12.50
Annotation	Intravenous delivery of therapeutic virus particles remains a major goal for virotherapy of metastatic cancer. Polymer coating of adenovirus type 5 (Ad5) can combine with predosing strategies or Kupffer cell ablation to achieve systemic kinetics with a half-life >60 min, allowing ready access to peripheral tumors. Polymer coating wild-type Ad5 in this way is known to decrease hepatic toxicity, increasing the dose of virus particles that can be safely administered. Using polymer-coating technology to deliver a replicating Ad5 systemically, virus replication and transgene expression was almost totally confined to tumor tissues, giving a much improved therapeutic index compared with uncoated virus, and complete control of human HepG2 tumor xenografts.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2013

Number of the records: 1