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Characterization of solid polymer dispersions of active pharmaceutical ingredients by 19F MAS NMR and factor analysis
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SYSNO ASEP 0383512 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Characterization of solid polymer dispersions of active pharmaceutical ingredients by 19F MAS NMR and factor analysis Author(s) Urbanová, Martina (UMCH-V) RID, ORCID
Brus, Jiří (UMCH-V) RID, ORCID
Šeděnková, Ivana (UMCH-V) RID
Policianová, Olivia (UMCH-V) RID
Kobera, Libor (UMCH-V) RID, ORCIDSource Title Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy. - : Elsevier - ISSN 1386-1425
Roč. 100, 1 January (2013), s. 59-66Number of pages 8 s. Language eng - English Country NL - Netherlands Keywords solid-state NMR ; factor analysis ; 19F MAS NMR Subject RIV FR - Pharmacology ; Medidal Chemistry R&D Projects GPP106/11/P426 GA ČR - Czech Science Foundation (CSF) 2B08021 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UMCH-V - RVO:61389013 CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000312181800009 DOI 10.1016/j.saa.2012.02.057 Annotation In this contribution the ability of 19F MAS NMR spectroscopy to probe structural variability of poorly water-soluble drugs formulated as solid dispersions in polymer matrices is discussed. The application potentiality of the proposed approach is demonstrated on a moderately sized active pharmaceutical ingredient (API, Atorvastatin) exhibiting extensive polymorphism. In this respect, a range of model systems with the API incorporated in the matrix of polvinylpyrrolidone (PVP) was prepared. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2013
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