Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides

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SYSNO ASEP	0382291
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides
Author(s)	Tichý, Michal (UOCHB-X)_{RID, ORCID} Pohl, Radek (UOCHB-X)_{RID, ORCID} Xu, H. Y. (SG) Chen, Y. L. (SG) Yokokawa, F. (SG) Shi, P. Y. (SG) Hocek, Michal (UOCHB-X)_{RID, ORCID}
Number of authors	7
Source Title	Bioorganic & Medicinal Chemistry. - : Elsevier - ISSN 0968-0896 Roč. 20, č. 20 (2012), s. 6123-6133
Number of pages	11 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	nucleosides ; deazapurines ; antivirals
Subject RIV	CC - Organic Chemistry
R&D Projects	GAP207/11/0344 GA ČR - Czech Science Foundation (CSF)
Institutional support	UOCHB-X - RVO:61388963
UT WOS	000309594200013
DOI	10.1016/j.bmc.2012.08.021
Annotation	A series of new pyrimido[4,5-b]indole ribonucleosides bearing phenyl or hetaryl group at position 4 has been prepared by selective Pd-catalyzed cross-coupling reactions of the corresponding protected 4,6-dichloropyrimido[4,5-b]indole ribonucleoside with (het)arylboronic acids or stannanes followed by deprotection. Some of these compounds displayed antiviral activity against Dengue virus.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2013

Number of the records: 1