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DNA conformation and repair of polymeric natural DNA damaged by antitumor azolato-bridged dinuclear PtII complex
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SYSNO ASEP 0381588 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title DNA conformation and repair of polymeric natural DNA damaged by antitumor azolato-bridged dinuclear PtII complex Author(s) Mlčoušková, J. (CZ)
Kašpárková, Jana (BFU-R) RID, ORCID
Suchánková, Tereza (BFU-R) RID, ORCID
Komeda, S. (JP)
Brabec, Viktor (BFU-R) RID, ORCIDNumber of authors 5 Source Title Journal of Inorganic Biochemistry. - : Elsevier - ISSN 0162-0134
Roč. 114, SEP 2012 (2012), s. 15-23Number of pages 9 s. Language eng - English Country US - United States Keywords DNA ; platinum ; DNA repair Subject RIV BO - Biophysics R&D Projects GAP301/10/0598 GA ČR - Czech Science Foundation (CSF) GD301/09/H004 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50040702 - BFU-R (2007-2013) UT WOS 000307413800003 DOI 10.1016/j.jinorgbio.2012.04.015 Annotation The results demonstrate for the first time that little conformational distortions induced by new antitumor azolato-bridged dinuclear PtII complexes, such as [{cis-Pt(NH3)2}2(µ-OH)(µ-pyrazolate)]2+ in highly polymeric DNA with a random nucleotide sequence represent a structural motif recognizable by DNA repair systems less efficiently than distortions induced by cisplatin. Thus, DNA adducts of azolato-bridged dinuclear PtII complexes can escape repair mechanisms more easily than those of cisplatin, which may potentiate antitumor effects of these new metallodrugs in cancer cells. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2013
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