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Protective effects of dexrazoxane against acute ischaemia/reperfusion injury of rat hearts

SYSNO ASEP	0380633
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Protective effects of dexrazoxane against acute ischaemia/reperfusion injury of rat hearts
Author(s)	Neckář, Jan (FGU-C)_{RID, ORCID} Boudíková, Adéla (FGU-C) Mandíková, Petra (FGU-C) Štěrba, M. (CZ) Popelová, O. (CZ) Mikšík, Ivan (FGU-C)_{RID, ORCID, SAI} Dabrowská, L. (CZ) Mráz, J. (CZ) Geršl, V. (CZ) Kolář, František (FGU-C)_{RID, ORCID, SAI}
Source Title	Canadian Journal of Physiology and Pharmacology. - : Canadian Science Publishing - ISSN 0008-4212 Roč. 90, č. 9 (2012), s. 1303-1310
Number of pages	8 s.
Language	eng - English
Country	CA - Canada
Keywords	heart ; dexrazoxane ; ischaemia ; reperfusion ; infarct size ; arrhythmias ; cardioprotection ; reactive oxygen species
Subject RIV	FR - Pharmacology ; Medidal Chemistry
R&D Projects	IAAX01110901 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	GA305/09/0416 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000308152200017
DOI	10.1139/y2012-096
Annotation	The aim of our study was to find out whether dexrazoxane (DEX) treatment reduces myocardial infarct size and arrhythmias induced by regional I/R in open-chest rats and in isolated perfused hearts, and to find out its most effective dose. Our results showed that DEX in the single dose of 150 mg•kg–1 effectively suppressed ventricular arrhythmias in isolated hearts subjected to acute I/R, but it was insufficient to reduce arrhythmias in open-chest animals, and only the highest dose of DEX (450 mg•kg–1) decreased myocardial infarct size. The protective effects of DEX were not accompanied by decreases of oxidative stress markers in the myocardium, suggesting that other protective mechanism(s) than limitation of ROS formation might play a role
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2013

Number of the records: 1