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Association analyses of porcine SERPINE1 reveal sex-specific effects on muscling, growth, fat accretion and meat quality
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SYSNO ASEP 0380412 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Association analyses of porcine SERPINE1 reveal sex-specific effects on muscling, growth, fat accretion and meat quality Author(s) Weisz, Filip (UZFG-Y) RID
Bartenschlager, H. (DE)
Knoll, Aleš (UZFG-Y)
Mileham, A. (US)
Deeb, N. (US)
Geldermann, H. (DE)
Čepica, Stanislav (UZFG-Y) RIDNumber of authors 7 Source Title Animal Genetics - ISSN 0268-9146
Roč. 43, č. 5 (2012), s. 614-619Number of pages 6 s. Language eng - English Country GB - United Kingdom Keywords association study ; fat deposition ; meat quality Subject RIV GI - Animal Husbandry ; Breeding R&D Projects GAP502/10/1216 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50450515 - UZFG-Y (2005-2011) UT WOS 000308330200018 DOI 10.1111/j.1365-2052.2011.02295.x Annotation The serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1) gene encodes plasminogen activator inhibitor type 1 (PAI), which is the major physiological inhibitor of tissue-type and urokinase-type plasminogen activators and plays a role in obesity and insulin resistance in women but not in men. We detected SNP FN396538:g.566G>A in intron 3 and a non-synonymous substitution NM-213910:c.612A>G in exon 3 (p.Ile159Val) and mapped the gene to position 8.4 cM on the linkage map of chromosome 3. Association analyses were conducted on the 12th-15th generation of the Meishan × Large White (MLW) cross (n = 565), with records for weight at the end of test, lifetime daily gain, test time daily gain, loin depth and backfat depth, as well as on a European wild boar × Meishan (W × M) F 2 population (n = 333) with 47 traits recorded for carcass composition and meat quality. Analyses performed across the entire MLW population or in the male animals did not show any trait significantly associated with the loci studied. In female animals, both SNPs were associated with loin depth at nominal P < 0.05 with adjusted P values equal to 0.051 (g.566) and 0.057 (c.612). Differences between homozygotes were up to 0.65 SD. In the entire W × M population and female animals, SERPINE1 was significantly associated at adjusted P < 0.05 in descending order with muscling, growth and fat accretion and in male animals with meat quality (R-value). In the studied populations, allele effects were in opposite directions, which implies that the SNPs are markers that are in linkage disequilibrium with a causative mutation Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2013
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