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Integrin alpha 5 beta 1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma
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SYSNO ASEP 0380296 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Integrin alpha 5 beta 1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma Author(s) Janoušková, Hana (FGU-C)
Maglott, A. (FR)
Leger, D.Y. (FR)
Bossert, C. (FR)
Noulet, F. (FR)
Guerin, E. (FR)
Guenot, D. (FR)
Pinel, S. (FR)
Chastagner, P. (FR)
Plenat, F. (FR)
Entz-Werle, N. (FR)
Lehmann-Che, J. (FR)
Godet, J. (FR)
Martin, S. (FR)
Teisinger, Jan (FGU-C) RID
Dontenwill, M. (FR)Source Title Cancer Research. - : American Association for Cancer Research - ISSN 0008-5472
Roč. 72, č. 14 (2012), s. 3463-3470Number of pages 8 s. Language eng - English Country US - United States Keywords cancer ; integrins ; high-grade glioma Subject RIV CE - Biochemistry Institutional support FGU-C - RVO:67985823 UT WOS 000307353200005 DOI 10.1158/0008-5472.CAN-11-4199 Annotation Integrins play a role in the resistance of advanced cancers to radiotherapy and chemotherapy. Our findings indicate that negative cross-talk between a5b1 integrin and p53 supports glioma resistance to temozolomide, providing preclinical proof-of-concept that a5b1 integrin represents a therapeutic target for high-grade brain tumors. Direct activation of p53 may remain a therapeutic option in the subset of patients with high-grade gliomas that express both functional p53 and a high level of a5b1 integrin Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2013
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