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Effect of tetrabrombisphenol A on induction of apoptosis in the testes and changes in expression of selected testicular genes in CD1 mice
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SYSNO ASEP 0380136 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Effect of tetrabrombisphenol A on induction of apoptosis in the testes and changes in expression of selected testicular genes in CD1 mice Author(s) Žatecká, Eva (BTO-N)
Děd, Lukáš (BTO-N) RID
Elzeinová, Fatima (BTO-N) RID
Kubátová, Alena (BTO-N) RID
Dorosh, Andriy (BTO-N) RID
Margaryan, Hasmik (BTO-N) RID
Dostálová, Pavla (BTO-N)
Pěknicová, Jana (BTO-N) RIDNumber of authors 8 Source Title Reproductive Toxicology. - : Elsevier - ISSN 0890-6238
Roč. 35, č. 1 (2013), s. 32-39Number of pages 8 s. Language eng - English Country US - United States Keywords tetrabromobisphenol A ; fertility ; reproductive parameters ; spermatogenesis ; histopathology of testes ; apoptosis ; gene expression Subject RIV EB - Genetics ; Molecular Biology R&D Projects 2B06151 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 1M06011 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) NS10009 GA MZd - Ministry of Health (MZ) GA523/09/1793 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000314003900005 DOI 10.1016/j.reprotox.2012.05.095 Annotation Tetrabromobisphenol A (TBBPA) is a substance widely used in industry as a flame retardant. TBBPA was found in the environment and was detected even in the human body. The effect of this chemical was observed in different cell lines in vitro and it is supposed that TBBPA may affect various hormonal systems in vivo. In this study we examined the effect of TBBPA on the reproductive parameters of two generations of outbred mice in vivo. Experimental and control animals of F1 generation were bred in various conditions to enable evaluation of the possible trans-generational effect. An increased incidence of apoptosis in the testes and changes in the morphometry of seminiferous tubules was detected in the experimental animals. In addition, changes in the expression pattern of selected genes encoding proteins that play an important role during spermatogenesis were observed. In contrast, sperm quality and reproduction were not affected by TBBPA. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2013
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