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Polymorphisms in miRNA binding sites of nucleotide excision repair genes and colorectal cancer risk
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SYSNO ASEP 0379749 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Polymorphisms in miRNA binding sites of nucleotide excision repair genes and colorectal cancer risk Author(s) Naccarati, Alessio (UEM-P)
Pardini, Barbara (UEM-P)
Landi, S. (IT)
Landi, D. (IT)
Slyšková, Jana (UEM-P) RID
Novotný, J. (CZ)
Levý, M. (CZ)
Poláková, Veronika (UEM-P) RID
Lipská, L. (CZ)
Vodička, Pavel (UEM-P) RIDSource Title Carcinogenesis. - : Oxford University Press - ISSN 0143-3334
Roč. 33, č. 7 (2012), s. 1346-1351Number of pages 6 s. Language eng - English Country GB - United Kingdom Keywords DNA repair ; polymorphisms ; miRNA binding sites Subject RIV EB - Genetics ; Molecular Biology R&D Projects GAP304/10/1286 GA ČR - Czech Science Foundation (CSF) GP305/09/P194 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000306925600013 EID SCOPUS 84865187699 DOI 10.1093/carcin/bgs172 Annotation Regulation of and coordination between DNA repair genes is fundamental for maintaining genome stability, and post-transcriptional gene regulation by microRNAs is of particular relevance. In this context, the presence of single nucleotide polymorphisms (SNPs) within the 3´-untranslated regions of target DNA repair genes could alter the binding with specific miRNAs,modulating gene expression and affecting cancer susceptibility. In this study, we investigated the role of genetic variations in miRNA-binding sites of nucleotide excision repair (NER) genes in association with colorectal cancer (CRC) risk. We tested those SNPs based on 28 NER genes in 1098 colorectal cancer cases and 1469 healthy controls from the Czech Republic. Rs7356 in RPA2 and rs4596 in GTF2H1 were associated with colorectal cancer risk. After stratification for tumor location, the association of both SNPs was significant only for rectal cancer (rs7356: OR 1.52, 95% CI 1.02–2.26, P = 0.04 and rs4596: OR 0.69, 95% CI 0.50–0.94, P = 0.02; results not adjusted for multiple testing). Variation in miRNA target binding sites in the 3´-untranslated region of NER genes may be important for modulating CRC risk, with a different relevance according to tumor location. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2013
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