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Cytoskeleton in mast cell signaling
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SYSNO ASEP 0378914 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Cytoskeleton in mast cell signaling Author(s) Dráber, Pavel (UMG-J) RID, ORCID
Sulimenko, Vadym (UMG-J) RID, ORCID
Dráberová, Eduarda (UMG-J) RID, ORCIDSource Title Frontiers in Immunology. - : Frontiers Media - ISSN 1664-3224
Roč. 3, May (2012), s. 130Number of pages 18 s. Publication form Online - E Language eng - English Country CH - Switzerland Keywords cytoskeleton ; mast cell activation ; signal transduction Subject RIV EB - Genetics ; Molecular Biology R&D Projects GAP302/10/1701 GA ČR - Czech Science Foundation (CSF) GPP302/11/P709 GA ČR - Czech Science Foundation (CSF) GAP302/12/1673 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50520514 - UMG-J (2005-2011) DOI 10.3389/fimmu.2012.00130 Annotation This review article presents a critical survey of current knowledge on the role of cytokeleton in mast cell signaling. Mast cell activation mediated by the high affinity receptor for IgE (FcεRI) is a key event in allergic response and inflammation. Activation of various signaling pathways results in changes in cell morphology, adhesion to substrate, exocytosis, and migration. Reorganization of cytoskeleton is pivotal in all these processes. Highly dynamic microtubules formed by αβ-tubulin dimers as well as microfilaments build up from polymerized actin are affected in activated cells by kinases/phosphatases, Rho GTPases and changes in concentration of cytosolic Ca2+. The dynamic nature of microtubules and microfilaments in activated cells also depends on many associated/regulatory proteins. In this review, we have summarized recent developments in the biology of cytoskeleton and the role of signaling pathways in the course of mast cell activation. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2013
Number of the records: 1