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Light scattering evidence of selective protein fouling on biocompatible block copolymer micelles

SYSNO ASEP	0378727
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Light scattering evidence of selective protein fouling on biocompatible block copolymer micelles
Author(s)	Giacomelli, F. C. (BR) Štěpánek, Petr (UMCH-V)_{RID, ORCID} Schmidt, V. (BR) Jäger, Eliezer (UMCH-V)_{ORCID, RID} Jäger, Alessandro (UMCH-V)_{RID, ORCID} Giacomelli, C. (BR)
Source Title	Nanoscale. - : Royal Society of Chemistry - ISSN 2040-3364 Roč. 4, č. 15 (2012), s. 4504-4514
Number of pages	11 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	copolymer micelles ; protein fouling ; light scattering
Subject RIV	CF - Physical ; Theoretical Chemistry
R&D Projects	GAP208/10/1600 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z40500505 - UMCH-V (2005-2011)
UT WOS	000306324000027
DOI	10.1039/c2nr30623a
Annotation	Selective protein fouling on block copolymer micelles with well-known potential for tumour-targeting drug delivery was evidenced by using dynamic light scattering measurements. The stability and interaction of block copolymer micelles with model proteins (BSA, IgG, lysozyme and CytC) is reported for systems featuring a hydrophobic (poly[2-(diisopropylamino)-ethyl methacrylate]) (PDPA) core and hydrophilic coronas comprising poly(ethylene oxide)/poly(glycerol monomethacrylate) (PEOb-PG2MA) or poly[2-(methacryloyloxy)ethyl phosphorylcholine] (PMPC). The results revealed that protein size and hydrophilic chain density play important roles in the observed interactions. The successful protein-repellent characteristic of these nanoparticles is attributed to a high hydrophilic surface chain density (>0.1 chains per nm2) and to the length of the hydrophilic chains.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2013

Number of the records: 1