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Locations and Reorientations of Multi-Ring-Fused 2-Pyridones in Ganglioside G(M1) Micelles
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SYSNO ASEP 0377559 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Locations and Reorientations of Multi-Ring-Fused 2-Pyridones in Ganglioside G(M1) Micelles Author(s) Šachl, Radek (UFCH-W) RID, ORCID
Rosenbaum, E. (SE)
Sellstedt, M. (SE)
Almqvist, F. (SE)
Johansson, L. B. A. (SE)Source Title Langmuir. - : American Chemical Society - ISSN 0743-7463
Roč. 27, č. 5 (2011), s. 1662-1667Number of pages 6 s. Language eng - English Country US - United States Keywords direct energy transfer ; fluorescent probe ; polymer mycelles Subject RIV CF - Physical ; Theoretical Chemistry R&D Projects GAP208/10/1090 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40400503 - UFCH-W (2005-2011) UT WOS 000287624700017 DOI 10.1021/la104051z Annotation Fluorescent multi-ring-fused 2-pyridones, with chemical resemblance to other biologically active 2-pyridone systems, were solubilized in spherical micelles formed by the gangloiside Gm, and studied with respect to their spatial localization and rotational mobility. For this, electronic energy transfer between the multi-ring-fused 2-pyridone (donor) and BODIPY-FL-labeled G(M1) was determined, as well as their fluorescence depolarization. From the obtained efficiency of energy transfer to the acceptor group (BODIPY-FL), either localized in the polar or in the nonpolar part of the ganglioside, it has been possible to estimate the most likely localization of the multi-ring-fused 2-pyridones. The center of mass of the studied multi-ring-fused 2-pyridones are located at approximately 33 angstrom from the micellar center of mass, which corresponds to the internal hydrophobic hydrophilic interfacial region. At this location, the reorienting rates of the multi-ring-fused 2-pyridones are surprisingly slow with typical correlation times of 35-55 ns. No evidence was found for the formation of ground and excited state dimers, even when two monomers were forced to be near each other via a short covalent linker. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2013
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