Number of the records: 1

Cryptosporidium tyzzeri and Cryptosporidium muris originated from wild West-European house mice (Mus musculus domesticus) and East-European house mice (Mus musculus musculus) are non-infectious for pigs

SYSNO ASEP	0377249
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Cryptosporidium tyzzeri and Cryptosporidium muris originated from wild West-European house mice (Mus musculus domesticus) and East-European house mice (Mus musculus musculus) are non-infectious for pigs
Author(s)	Kváč, Martin (BC-A)_{RID, RID, ORCID} Kestřánová, M. (CZ) Květoňová, Dana (BC-A)_SAI Kotková, M. (CZ) Ortega, Y. (US) McEvoy, J. (US) Sak, Bohumil (BC-A)_{RID, ORCID}
Source Title	Experimental Parasitology. - : Elsevier - ISSN 0014-4894 Roč. 131, č. 1 (2012), s. 107-110
Number of pages	4 s.
Language	eng - English
Country	US - United States
Keywords	Pigs ; Cryptosporidium tyzzeri ; Cryptosporidium muris ; Experimental infection ; PCR ; Histology
Subject RIV	GJ - Animal Vermins ; Diseases, Veterinary Medicine
R&D Projects	LH11061 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	BC-A - RVO:60077344
UT WOS	000303956100018
DOI	10.1016/j.exppara.2012.03.016
Annotation	Three and 8 week old pigs were inoculated with Cryptosporidium muris HZ206 (Mus musculus musculus isolate), Cryptosporidium tyzerri CR2090 (M. m. musculus isolate) or C. tyzzeri CR4293 (isolate from a hybrid between Mus musculus domesticus and M. m. musculus) at a dose of 1 _ 107 oocysts per animal. Inoculated pigs showed no detectable infection and no clinical symptoms of cryptosporidiosis during 30 days post infection (DPI), and no macroscopic changes were detected in the digestive tract following necropsy. Developmental stages were not detected in gastrointestinal tract tissue by histology or PCR throughout the duration of the experiment. The infectivity of isolates was verified on SCID mice, in which oocysts shedding started from 4 to 8 DPI. Based on our findings, it can be concluded that pigs are not susceptible to C. muris or C. tyzzeri infection.
Workplace	Biology Centre (since 2006)
Contact	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Year of Publishing	2013
Electronic address	http://www.sciencedirect.com/science/article/pii/S0014489412001105

Number of the records: 1