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Cytoskeleton and Human Disease
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SYSNO ASEP 0375940 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Microtubules Author(s) Dráber, Pavel (UMG-J) RID, ORCID
Dráberová, Eduarda (UMG-J) RID, ORCIDSource Title Cytoskeleton and Human Disease. - New York : Humana Press, 2012 / Kavallaris M. - ISBN 978-1-61779-787-3 Pages s. 29-54 Number of pages 26 s. Number of pages 447 Publication form Print - P Language eng - English Country US - United States Keywords microtubules nucleation ; dynamics ; regulation Subject RIV EB - Genetics ; Molecular Biology R&D Projects GAP302/10/1701 GA ČR - Czech Science Foundation (CSF) GA204/09/1777 GA ČR - Czech Science Foundation (CSF) LC545 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50520514 - UMG-J (2005-2011) DOI 10.1007/978-1-61779-788-0 Annotation The chapter 2 covers normal structure and function of microtubules cytoskeleton. Authors focus in deeper details the regulation of microtubules nucleation and their dynamics. At the beginning there is structural description of key microtubular components that follow through basic principals of microtubule dynamics also description of tubulin isotypes. In next part, there is exhaustive view into mechanisms of microtubule nucleation by γ-tubulin a post-translational modification of the most important members of tubulin superfamily. The last part of the chapter represents large inside to microtubule-regulatory proteins that include group of microtubule associated proteins, severing proteins, disassembly and assembly promoters and plus-end tracking proteins. This chapter forms an integral part of the book. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2013
Number of the records: 1