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The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-Cell 17 population
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SYSNO ASEP 0375938 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-Cell 17 population Author(s) Svobodová, Eliška (UMG-J)
Krulová, Magdalena (UMG-J)
Zajícová, Alena (UMG-J)
Pokorná, Kateřina (UMG-J)
Procházková, Jana (UMG-J)
Trošan, Peter (UMG-J)
Holáň, Vladimír (UMG-J)Source Title Stem Cells and Development. - : Mary Ann Liebert - ISSN 1547-3287
Roč. 21, č. 6 (2012), s. 901-910Number of pages 10 s. Language eng - English Country US - United States Keywords mesenchymal stem cells ; immunomodulation ; T-cell development Subject RIV EB - Genetics ; Molecular Biology R&D Projects KAN200520804 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) 1M0506 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GAP304/11/0653 GA ČR - Czech Science Foundation (CSF) GD310/08/H077 GA ČR - Czech Science Foundation (CSF) GAP301/11/1568 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000302222700008 DOI 10.1089/scd.2011.0157 Annotation Bone marrow-derived mesenchymal stem cells (MSCs) can produce significant levels of transforming growth factor-β and interleukin-6. These two cytokines represent the key factors that reciprocally regulate the development of naive T-cells into regulatory T-cell (Treg) population or proinflammatory T helper 17 (Th17) cells. We demonstrated that MSCs and their products effectively regulate expression of transcription factors Foxp3 and RORγt and control the development of Tregs and Th17 cells in a population of alloantigen-activated mouse spleen cells. The immunomodulatory effects of MSCs were more pronounced when these cells were stimulated by addition of anti-inflammatory or proinflammatory cytokines. The results showed that MSCs represent important players that reciprocally regulate the differentiation of naive T-cells into anti-inflammatory Tregs or proinflammatory Th17 cell population and thereby can modulate immunopathological or transplantation reactions. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2013
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