Number of the records: 1
Effect of tick saliva on immune interactions between Borrelia afzelii and murine dendritic cells
- 1.
SYSNO ASEP 0373440 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Effect of tick saliva on immune interactions between Borrelia afzelii and murine dendritic cells Author(s) Slámová, M. (CZ)
Skallová, A. (CZ)
Páleníková, J. (CZ)
Kopecký, Jan (BC-A) RIDSource Title Parasite immunology. - : Wiley - ISSN 0141-9838
Roč. 33, č. 12 (2011), 654-660Number of pages 7 s. Language eng - English Country GB - United Kingdom Keywords Borrelia ; dendritic cell ; immune modulation ; Ixodes ricinus Subject RIV EC - Immunology R&D Projects IAA600960811 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) LC06009 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) UT WOS 000297744000002 DOI 10.1111/j.1365-3024.2011.01332.x Annotation Interaction between mouse dendritic cells (DCs) and Borrelia afzelii spirochetes was monitored on three different levels: phagocytosis of spirochetes by DCs, production of cytokines by Borrelia-stimulated DCs and the ability of Borrelia-exposed DCs to activate specific CD4+ T lymphocytes. The effect of Ixodes ricinus tick saliva on each of these interactions was examined. Tick saliva was shown to decrease the number of phagocytosing DCs. The ability of Borrelia-exposed DCs to induce both proliferation and IL-2 production by specific CD4+ T cells was significantly reduced by tick saliva. And surprisingly, we have shown an inhibitory effect of tick saliva on the production of both Th1 (TNF-alpha and IL-6) and Th2 (IL-10) cytokines by DCs. Our data reveal a complex inhibitory effect of tick saliva on Borrelia-DCs interaction. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2012
Number of the records: 1