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Coordination conjugates of therapeutic proteins with drug carriers: A new approach for versatile advanced drug delivery
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SYSNO ASEP 0372287 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Coordination conjugates of therapeutic proteins with drug carriers: A new approach for versatile advanced drug delivery Author(s) Kejík, Z. (CZ)
Bříza, T. (CZ)
Králová, Jarmila (UMG-J) RID
Poučková, P. (CZ)
Kral, A. (CZ)
Martásek, P. (CZ)
Král, V. (CZ)Source Title Bioorganic and Medicinal Chemistry Letters. - : Elsevier - ISSN 0960-894X
Roč. 21, č. 18 (2011), s. 5514-5520Number of pages 7 s. Language eng - English Country GB - United Kingdom Keywords combined cancer therapy ; photodynamic therapy ; targeted drug delivery Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA203/09/1311 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000294051800080 DOI 10.1016/j.bmcl.2011.06.101 Annotation We present here a general system for the coordination attachment of therapeutic proteins to a drug delivery system and its application in combined therapy. Proof of concept is demonstrated by the synthesis and testing of the targeted drug delivery system for cytostatics, which is based on a combination of the drug carrier Zn-porphyrin-cyclodextrin conjugates and their supramolecular coordination complexes with immunoglobulins. This system can be as readily used for a variety of therapeutic and targeting proteins including PAs, MAs, lectins, and HSA. Moreover, it allows combined photodynamic therapy, cell targeted chemotherapy and immunotherapy. When tested in a mouse model with human C32 carcinoma, the therapeutic superiority of the coordination assembly nanosystem was shown in comparison with the efficacy of building blocks used for the construction of the system. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2012
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