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Spatial Navigation and APOE in Amnestic Mild Cognitive Impairment
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SYSNO ASEP 0370885 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Spatial Navigation and APOE in Amnestic Mild Cognitive Impairment Author(s) Laczó, J. (CZ)
Andel, R. (US)
Vlček, Kamil (FGU-C) RID, ORCID
Maťoška, V. (CZ)
Vyhnálek, M. (CZ)
Tolar, M. (US)
Bojar, M. (CZ)
Hort, J. (CZ)Source Title Neurodegenerative Diseases. - : Karger - ISSN 1660-2854
Roč. 8, č. 4 (2011), s. 169-177Number of pages 9 s. Language eng - English Country CH - Switzerland Keywords mild cognitive impairment ; spatial navigation ; Alzheimer's disease Subject RIV FH - Neurology R&D Projects GA309/09/0286 GA ČR - Czech Science Foundation (CSF) GA309/09/1053 GA ČR - Czech Science Foundation (CSF) 1M0517 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000290559000002 DOI 10.1159/000321581 Annotation We found more profound deficits in spatial navigation in aMCI E4 positive relative to aMCI E4 negative patients. The aMCI E4 positive group resembled the mild AD group in spatial navigation performance. Although E4 genotype was indicative of spatial navigation performance, it was not indicative of the aMCI patients’ ability to learn the tasks. Spatial navigation testing represents a promising area with respect to identifying individuals at higher risk for AD among the heterogeneous MCI population Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2012
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