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Assessment of Mitochondrial DNA as an Indicator of Islet Quality: An Example in Goto Kakizaki Rats
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SYSNO ASEP 0370179 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Assessment of Mitochondrial DNA as an Indicator of Islet Quality: An Example in Goto Kakizaki Rats Author(s) Alán, Lukáš (FGU-C) RID, ORCID
Špaček, Tomáš (FGU-C) RID, ORCID
Zelenka, Jaroslav (FGU-C) RID
Tauber, Jan (FGU-C) RID, ORCID
Berková, Z. (CZ)
Zacharovová, K. (CZ)
Saudek, F. (CZ)
Ježek, Petr (FGU-C) RID, ORCIDSource Title Transplantation Proceedings. - : Elsevier - ISSN 0041-1345
Roč. 43, č. 9 (2011), s. 3281-3284Number of pages 4 s. Action World Congress of the International Pancreas and Islet Transplant Association /13./ Event date 01.06.2011-04.06.2011 VEvent location Praha Country CZ - Czech Republic Event type WRD Language eng - English Country US - United States Keywords type 2 diabetes ; mtDNA ; beta-cells Subject RIV FB - Endocrinology, Diabetology, Metabolism, Nutrition R&D Projects NS10219 GA MZd - Ministry of Health (MZ) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000297485500034 DOI 10.1016/j.transproceed.2011.09.055 Annotation Diabetic Goto Kakizaki (GK) rats represent an established model of type 2 diabetes that exhibit an onset of pancreatic islet (PI) pathology characterized by islet hypertrophy with decreased number of insulin-secreting beta-cells. Among the remaining beta-cells, oxidative phosphorylation (OXPHOS) and consequently glucose-stimulated insulin secretion (GSIS) are impaired, perhaps owing to a deficit in mitochondrial DNA (mtDNA). We measured content of mtDNA compared to Wistar rats in different tissues and we found drastic decrease in number of mtDNA Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2012
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