Number of the records: 1

Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells

SYSNO ASEP	0370173
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells
Author(s)	Smolková, Katarína (FGU-C)_{RID, ORCID, SAI} Plecitá-Hlavatá, Lydie (FGU-C)_{RID, ORCID} Bellance, N. (FR) Benard, G. (FR) Rossignol, R. (FR) Ježek, Petr (FGU-C)_{RID, ORCID}
Source Title	International Journal of Biochemistry and Cell Biology. - : Elsevier - ISSN 1357-2725 Roč. 43, č. 7 (2011), s. 950-968
Number of pages	19 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	metabolic changes ; mitochondria ; carcinogenesis
Subject RIV	ED - Physiology
R&D Projects	NR7778 GA MZd - Ministry of Health (MZ)
	ME09029 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	IAA500110701 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000292362200003
DOI	10.1016/j.biocel.2010.05.003
Annotation	In this review authors posit following hypothesis: Independently of whether malignant tumors are initiated by a fundamental reprogramming of gene expression or seeded by stem cells, waves of gene expression that promote metabolic changes occur during carcinogenesis, beginning with oncogene-mediated changes, followed by hypoxia-induced factor (HIF)-mediated gene expression, both resulting in the highly glycolytic Warburg phenotype and suppression of mitochondrial biogenesis
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2012

Number of the records: 1