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HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat
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SYSNO ASEP 0370143 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat Author(s) Fun, A. (NL)
Maarseveen van, N. M. (NL)
Pokorná, Jana (UOCHB-X) RID
Maas, R. E. (NL)
Schipper, P. J. (NL)
Konvalinka, Jan (UOCHB-X) RID, ORCID
Nijhuis, M. (NL)Number of authors 7 Source Title Retrovirology. - : BioMed Central
Roč. 8, č. 70 (2011), s. 1-12Number of pages 12 s. Language eng - English Country GB - United Kingdom Keywords immunodeficiency-virus type-1 ; gag spacer peptide-1 ; replication capacity ; compensatory mutations ; cleavage sites Subject RIV CE - Biochemistry CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000295599200001 DOI 10.1186/1742-4690-8-70 Annotation Maturation inhibitors are an experimental class of antiretrovirals that inhibit Human Immunodeficiency Virus (HIV) particle maturation, the structural rearrangement required to form infectious virus particles. This rearrangement is triggered by the ordered cleavage of the precursor Gag polyproteins into their functional counterparts by the viral enzyme protease. In contrast to protease inhibitors, maturation inhibitors impede particle maturation by targeting the substrate of protease (Gag) instead of the protease enzyme itself. Direct cross-resistance between protease and maturation inhibitors may seem unlikely, but the co-evolution of protease and its substrate, Gag, during protease inhibitor therapy, could potentially affect future maturation inhibitor therapy. Previous studies showed that there might also be an effect of protease inhibitor resistance mutations on the development of maturation inhibitor resistance, but the exact mechanism remains unclear. We used wild-type and protease inhibitor resistant viruses to determine the impact of protease inhibitor resistance mutations on the development of maturation inhibitor resistance. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2012
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