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Association of CD99 short and long forms with MHC class I, MHC class II and tetraspanin CD81 and recruitment into immunological synapses
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SYSNO ASEP 0370115 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Association of CD99 short and long forms with MHC class I, MHC class II and tetraspanin CD81 and recruitment into immunological synapses Author(s) Pata, S. (TH)
Otáhal, Pavel (UMG-J) RID
Brdička, Tomáš (UMG-J) RID
Laopajon, W. (TH)
Mahasongkram, K. (TH)
Kasinrer, W. (TH)Source Title BMC Research Notes. - : Springer - ISSN 1756-0500
Roč. 4, - (2011), s. 293Number of pages 13 s. Publication form http://www.biomedcentral.com/1756-0500/4/293 - http://www.biomedcentral.com/1756-0500/4/293 Language eng - English Country GB - United Kingdom Keywords CD99 ; MHC II ; CD81 Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z50520514 - UMG-J (2005-2011) DOI 10.1186/1756-0500-4-293 Annotation We analyzed the association of CD99 with other cell surface molecules involved in T cell activation. We demonstrate the association of MHC class I, MHC class II and tetraspanin CD81 with CD99 molecules on the cell surface. Association of CD99 with its partners was observed for both isoforms. In addition, we determined that CD99 is a lipid raft-associated membrane protein and is recruited into the immunologic synapse during T cell activation. The implication of CD99 on T cell activation was investigated. Inhibition of anti-CD3 induced T cell proliferation by an anti-CD99 monoclonal antibody was observed. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2012
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