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Crystal structure of a monomeric retroviral protease solved by protein folding game players
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SYSNO ASEP 0369853 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Crystal structure of a monomeric retroviral protease solved by protein folding game players Author(s) Khatíb, F. (US)
Dímaio, F. (US)
Cooper, S. (US)
Kazmierczyk, M. (PL)
Gilski, M. (PL)
Krzywda, S. (PL)
Zábranská, Helena (UOCHB-X) RID
Pichová, Iva (UOCHB-X) RID, ORCID
Thompson, J. (US)
Popovic, Z. (US)
Jaskolski, M. (PL)
Baker, D. (US)Number of authors 12 Source Title Nature Structural & Molecular Biology. - : Nature Publishing Group - ISSN 1545-9993
Roč. 18, č. 10 (2011), s. 1175-1177Number of pages 3 s. Language eng - English Country US - United States Keywords M-MPV protease ; monomer ; model ; Foldit Subject RIV CE - Biochemistry R&D Projects 1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000295931400014 DOI 10.1038/nsmb.2119 Annotation Following the failure of a wide range of attempts to solve the crystal structure of M-PMV retroviral protease by molecular replacement, we challenged players of the protein folding game Foldit to produce accurate models of the protein. Remarkably, Foldit players were able to generate models of sufficient quality for successful molecular replacement and subsequent structure determination. The refined structure provides new insights for the design of antiretroviral drugs. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2012
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