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Polyglutamate copolymers as a tissue-engineering platform: polymer scaffold modification through aminolysis of poly(.gamma.-benzyl-L-glutamate-co-2,2,2-.gamma.-trichlorethyl-L-glutamate)
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SYSNO ASEP 0369730 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Polyglutamate copolymers as a tissue-engineering platform: polymer scaffold modification through aminolysis of poly(.gamma.-benzyl-L-glutamate-co-2,2,2-.gamma.-trichlorethyl-L-glutamate) Author(s) Svobodová, Jana (UMCH-V) RID, ORCID
Rypáček, František (UMCH-V) RIDSource Title European Polymer Journal. - : Elsevier - ISSN 0014-3057
Roč. 48, č. 1 (2012), s. 183-190Number of pages 8 s. Language eng - English Country GB - United Kingdom Keywords poly(.gamma.-benzyl-L-glutamate) ; 2,2,2-.gamma.-trichlorethyl-L-glutamate ; fibres Subject RIV CD - Macromolecular Chemistry R&D Projects KJB400500904 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GAP108/11/1857 GA ČR - Czech Science Foundation (CSF) 1M0538 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000300078700019 DOI 10.1016/j.eurpolymj.2011.10.019 Annotation Homopolymers of γ-benzyl-L-glutamate (BLG) and its copolymers with more reactive 2,2,2-γ-trichlorethyl-L-glutamate (TCEG) were synthesized by ROP of respective N-carboxyanhydrides (NCA). The feasibility of functional modification of polyglutamate films and fibres through aminolysis of glutamate side chains with 2-aminoethanol or with a 2-aminoethanol/1,6-diaminohexane mixture was studied. The progress and extent of polymer side chain modification were analyzed by following methods: (a) the conversion of aminolysis of BLG units alone was determined from the amount of released benzyl alcohol extracted into hexane and followed by HPLC analysis, (b) the conversion of aminolysis of TCEG units was calculated from elemental analysis, (c) the depth and extend of films surface modification was evaluated ATR IR measurements and (d) the amount of free amino groups, created by aminolysis with 1,6-diaminohexane, was quantified by reaction with 2,4,6-trinitrobenzenesulfonic acid. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2012
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