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Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies
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SYSNO ASEP 0369728 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies Author(s) Váchová, Libuše (MBU-M) RID, ORCID
Šťovíček, V. (CZ)
Hlaváček, Otakar (MBU-M) RID, ORCID
Chernyavskiy, Oleksandr (FGU-C)
Štěpánek, L. (CZ)
Kubínová, Lucie (FGU-C) RID, ORCID
Palková, Z. (CZ)Source Title Journal of Cell Biology. - : Rockefeller University Press - ISSN 0021-9525
Roč. 194, č. 5 (2011), s. 679-687Number of pages 9 s. Language eng - English Country US - United States Keywords CANDIDA-ALBICANS BIOFILMS ; SACCHAROMYCES-CEREVISIAE ; ABC TRANSPORTERS Subject RIV EE - Microbiology, Virology R&D Projects GA204/08/0718 GA ČR - Czech Science Foundation (CSF) LC531 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LC06063 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50200510 - MBU-M (2005-2011) AV0Z50110509 - FGU-C (2005-2011) UT WOS 000294602500006 DOI 10.1083/jcb.201103129 Annotation The molecular mechanisms underlying the spatiotemporal development and environmental resistance of biofilms and colonies remain largely unknown. We show that a biofilm yeast colony is a finely tuned, complex ’multicellular organism‘, in which specialized cells jointly execute multiple protection strategies. These include a Pdr1p-regulated mechanism whereby multidrug-resistance transporters Pdr5p and Snq2p expel external compounds solely within the surface cell layers, as well as developmentally regulated production by internal cells of a selectively permeable extracellular matrix. The two mechanisms act in concert during colony development, allowing growth of new cell generations in a well protected, internal cavity of the colony. Colony architecture is strengthened by intercellular fiber connections Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2012
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