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Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress
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SYSNO ASEP 0369512 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress Author(s) Ito, K. (AU)
Scott, S.A. (AU)
Cutler, S. (AU)
Dong, L.-F. (AU)
Neužil, Jiří (BTO-N) RID
Blanchard, H. (AU)
Ralph, S.J. (AU)Source Title Angiogenesis - ISSN 0969-6970
Roč. 14, č. 3 (2011), s. 293-307Number of pages 15 Language eng - English Country NL - Netherlands Keywords Galectin-1 inhibitor ; oxidative stress ; angiogenesis Subject RIV FD - Oncology ; Hematology CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000293922300007 DOI 10.1007/s10456-011-9213-5 Annotation Cancer cells produce galectin-1 as a tumor promoting protein. Thiodigalactoside (TDG) as a non-metabolised drug, is shown to suppress tumor growth by inhibiting cancer enhancing activities of galectin-1, including immune cell dysregulation, angiogenesis and protection against oxidative stress. Using B16F10 melanoma and 4T1 orthotopic breast cancer models, intratumoral injection of TDG significantly raised the levels of infiltrating CD8(+) lymphocytes and reduced CD31(+) endothelial cell content, reducing tumor growth. TDG treatment of tumors in Balb/c nude mice reduced angiogenesis and slowed tumor growth by a third less than in immunocompetent mice. Knocking down galectin-1 expression (G1KD) significantly impeded tumor growth and the sensitivity of the G1KD tumors to TDG was severely reduced. Endothelial cells were protected by galectin-1 from oxidative stress-induced apoptosis, but TDG inhibited this antioxidant protective effect of galectin-1 and reduced tube forming activity. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2012
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